Doctors have a hard time dealing with the weight gain that comes with antipsychotics. Studies have shown that weight gain and obesity are associated with increased cardiovascular and cerebrovascular morbidity and mortality, worse quality of life, and poor medication adherence. This narrative review looks at how certain antipsychotics may make people gain weight, the drugs and other treatments that can help with this, and how it affects adherence. Most antipsychotics make people gain weight. It seems that olanzapine and clozapine have the highest risk. Weight gain happens fast in the first few weeks after starting antipsychotics. Patients keep becoming heavier over time. Kids appear to acquire more weight than adults when they use antipsychotics. The best strategies to prevent issues from happening at start are to tailor antipsychotics to each person's needs and keep a close check on their weight and other metabolic parameters. You could switch to a medicine that doesn't help you gain weight as much, but this might make your disease come back. Non-drug treatments, such dietary counseling, fitness programs, and cognitive and behavioral approaches, work just as well in individual and group therapy settings. Both nonpharmacologic preventive and therapeutic strategies have shown little effectiveness in weight control. Many chemicals have been investigated as supplementary agents for weight loss. In this case, metformin has the most evidence. You need to consider about how serious the side effects will be before handing out weight loss pills. There is inadequate evidence to support the routine prescription of supplementary medication for weight reduction. The diversity of study methodologies and several confounding variables, including lifestyle, genetic, and health-related factors, hinder data interpretation.