Tele pharmacy services are a means of enhancing medication adherence among older persons (60 years of age and older), especially those with chronic diseases who take many drugs. The purpose of this study was to identify the variables affecting older individuals' use of telepharmacy services in terms of medication adherence (MA). The scoping review approach developed by the Joana Briggs Institute was used. The databases PubMed, Scopus, ProQuest, Web of Science, and Embase were searched from 2000 to the present to find qualitative and quantitative research on older adults' use of telepharmacy. A qualitative method was used to extract and analyze the factors influencing MA into themes. Additionally, a concept map that summarized these elements was created. Findings: 52 articles out of the 7495 that were found during the first search satisfied the requirements for inclusion. Five topics and twenty-one sub-themes that represented the elements influencing MA with tele-pharmacy emerged from the analysis. These themes can be broadly categorized into two categories: technology and factors linked to users. The telepharmacy intervention's design, its commercial characteristics, and the technique for measuring adherence were all considered technological issues. User-health limitations, habits, and attitudes were among the user factors. In order to improve medication adherence among older adults, industry, policymakers, and stakeholders should think about utilizing telepharmacy services. However, for technology adoption and efficacy, it is crucial that interventions facilitate communication between patients and health care teams and are supported by user training.