Medication adherence and persistence are acknowledged as a global public health issue, especially critical in the treatment of chronic disorders. No adherence to medical plans impacts all demographics, notably older persons, owing to their prevalence of comorbidities and resultant polypharmacy. Managing a chronic condition means constantly changing how you think and act. Numerous strategies aimed at enhancing medication adherence have been documented in the literature for various clinical disorders; nevertheless, the majority of these interventions seem to be ineffective in achieving their objectives. Furthermore, the majority of therapies linked to enhancements in adherence do not correlate with increases in other outcomes. In fact, the level of nonadherence has not altered in the previous several decades. In this study, we examine the most prevalent methods used to enhance medication adherence, the assessed outcomes, and the resultant changes, while also highlighting the primary limitations of existing research on adherence, particularly for older adults.