n this time of new discoveries, the oral-based drug delivery system is moving very quickly. The world is moving toward new types of medicine, but since the beginning of drug research, pharmaceutical scientists have had to deal with problems with solubility and bioavailability. The nanoemulsions are the greatest formulations for increasing the bioavailability of medications that don't dissolve. Because of the pandemic, a lot of study has been done in the last three years. During this time, most countries have focused on scientific and medical research. Recently, quercetin hydrate has been discovered to exhibit anti-malarial properties, with its bioavailability enhanced through the application of Nanoemulsion formulations. The authors employed a high-energy methodology to formulate the nanoemulsions, utilizing design expert software that facilitated the identification of the requisite number of trials. Different tools are utilized to make new medication delivery systems work better. These tools are helpful since they cut down on the number of experiments and the amount of expensive reagents that are wasted. The reason for choosing a Central Composite Design (CCD) was that it needed fewer runs than alternative designs. The design specialist said that CCD software was available for 17 runs, which meant 17 groups or formulations. The experimental design created batches that were tested for size and dispersibility of the globules. Quercetin hydrate has been licensed as a treatment for a number of conditions, but its clinical use is still limited by its low oral bioavailability, which is caused by its low solubility in water and unpredictable absorption. A nanoemulsion made from Opuntia ficus indica seed oil, PEG400, tween 80, and ethanol and loaded with quercetin hydrate produced nano-sized particles that improve medication solubility and bioavailability. This investigation showed how important nanoemulsion is for making Quercetin hydrate more bioavailable.