Antimicrobial resistance is a critical problem across the world that puts both public health and healthcare workers at risk. Since penicillin was discovered, numerous antibiotics have stopped working against microorganisms because they were used too much, for no good reason, or without any restrictions. The ineffectiveness of a growing number of antibiotics demands the use of increasingly strong antimicrobial medicines to tackle simple illnesses. The Antimicrobial Stewardship Program was created and put into action because the number of multidrug-resistant organisms was going up and there was a need to cut down on the need for new medicines. A lead physician, preferably with experience in infectious illnesses, a pharmacist as a secondary leader, and a microbiologist with specific duties are all part of this project. Their goal is to reach numerous goals. These goals include cutting down on the random use of antimicrobial agents, encouraging the use of specific antimicrobial agents based on culture findings, moving from broad-spectrum to focused antimicrobial agents in treatment, and switching from parenteral to oral administration where possible. We use both pre-prescription and post-prescription techniques to achieve these goals. The Antimicrobial Stewardship Program is well-established in wealthy countries, but it has to be put into place more fully in less developed areas. This study seeks to analyze the tactics used in antimicrobial stewardship programs to assess their efficacy in avoiding the emergence of multidrug-resistant organisms (MDROs) according to current research studies. The Antimicrobial Stewardship Program has helped stop the rise of multidrug-resistant organisms by teaching healthcare workers and constantly sharing information on antimicrobial resistance.