There are potential health risks associated with improper medication usage, and there is growing evidence that adverse drug responses are frequent but often avoidable. People often use over-the-counter medications for self-medication. It is considered a crucial aspect of self-care. In Libya, the use of over-the-counter medications, such as analgesics, by children and adolescents is steadily rising. This is a significant public health issue. The purpose of this research is to examine the phenomenon of adolescents self-medicating by using over-the-counter medications to cure both minor and major illnesses. This study used a survey containing a variety of questions to gather data on teens who purchased prescription-free medications from private pharmacies at two separate secondary schools in Benghazi, Libya. There were 120 pupils in the sample, 58 of whom were male and 62 of whom were female, and they ranged in age from 15 to 18. Questionnaire data were examined for trends in medication usage. Compared to female adolescents, male adolescents purchased more toothache and muscle-spasm medications. However, compared to male adolescents, female adolescents administered more over-the-counter drugs each month. Teenagers in secondary school have been discovered to utilize over-the-counter medications in a highly rated and exaggerated manner. In conclusion, it is necessary to educate Libyan teenagers on the usage of over-the-counter medications. Promoting the proper use of medications within the healthcare system is a crucial issue. An instructional plan including several public sectors, including health and education agencies, may accomplish this.